Fearless: Ally Siegel

Encouraging and mentoring young minds, consistently finding new ways to use her love of climbing and adventure to promote character and leadership development, and always ready for the next big challenge, Ally Siegel ’16 fearlessly pushes herself to achieve more, inspiring others to do the same. [excerpt

Reading-related skills of kindergarteners from diverse linguistic backgrounds

This study examined whether measures used to identify children at risk for reading failure are appropriate for children from different language backgrounds. Tasks assessing literacy and phonological and language processing at the beginning and end of kindergarten were administered to 540 native English speakers (NS), 59 bilingual children (BL), and 60 children whose initial exposure to English was when they began school (ESL). Although the BL and ESL children performed more poorly than the NS children on most measures of phonological and linguistic processing, the acquisition of basic literacy skills for children with different language backgrounds developed in a similar manner. Furthermore, planned contrasts between the language groups did not explain the variance in the children’s literacy performance in May. Instead, alphabetic knowledge and phonological processing were important contributors to early reading skill. Therefore, children learning English may acquire literacy skills in English in a similar manner to NS children, although their alphabetic knowledge may precede and facilitate the acquisition of phonological awareness in English

Kingdom of trolls? Influence operations in the Saudi Twittersphere

Saudi Arabia has one of the highest rates of Twitter penetration in the world. Despite high levels of repression, the platform is frequently used to discuss political topics. Recent disclosures from Twitter have revealed state-backed attempts at distorting the online information environment through influence operations (IOs). A growing body of research has investigated online disinformation and foreign-sponsored IOs in the English-speaking world; but comparatively little is known about online disinformation in other contexts or about the domestic use of IOs. Using public releases of IO tweets, we investigate the extent of such activity in Saudi Arabia. Benchmarking these tweets to four samples of Saudi Twitter users, we find that engagement with IO accounts was lower than engagement with the average user, but equal to engagement with news accounts. Network analysis reveals that engagement with IO accounts was largely driven by a small number of influential accounts

Social media, political polarization, and political disinformation: a review of the scientific literature

The following report is intended to provide an overview of the current state of the literature on the relationship between social media; political polarization; and political “disinformation,” a term used to encompass a wide range of types of information about politics found online, including “fake news,” rumors, deliberately factually incorrect information, inadvertently factually incorrect information, politically slanted information, and “hyperpartisan” news. The review of the literature is provided in six separate sections, each of which can be read individually but that cumulatively are intended to provide an overview of what is known — and unknown — about the relationship between social media, political polarization, and disinformation. The report concludes by identifying key gaps in our understanding of these phenomena and the data that are needed to address them

Social media, political polarization, and political disinformation: a review of the scientific literature

The following report is intended to provide an overview of the current state of the literature on the relationship between social media; political polarization; and political “disinformation,” a term used to encompass a wide range of types of information about politics found online, including “fake news,” rumors, deliberately factually incorrect information, inadvertently factually incorrect information, politically slanted information, and “hyperpartisan” news. The review of the literature is provided in six separate sections, each of which can be read individually but that cumulatively are intended to provide an overview of what is known — and unknown — about the relationship between social media, political polarization, and disinformation. The report concludes by identifying key gaps in our understanding of these phenomena and the data that are needed to address them

Defining Refractory Migraine: Results of the RHSIS Survey of American Headache Society Members

To gauge consensus regarding a proposed definition for refractory migraine proposed by Refractory Headache Special Interest Section, and where its use would be most appropriate. Background.— Headache experts have long recognized that a subgroup of headache sufferers remains refractory to treatment. Although different groups have proposed criteria to define refractory migraine, the definition remains controversial. The Refractory Headache Special Interest Section of the American Headache Society developed a definition through a consensus process, assisted by a literature review and initial membership survey. Design.— A 12-item questionnaire was distributed at the American Headache Society meeting in 2007 during a platform session and at the Refractory Headache Special Interest Section symposium. The same questionnaire was subsequently sent to all American Headache Society members via e-mail. A total of 151 responses from AHS members form the basis of this report. The survey instrument was designed using Survey Monkey. Frequencies and percentages of the survey were used to describe survey responses. Results.— American Headache Society members agreed that a definition for refractory migraine is needed (91%) that it should be added to the International Classification of Headache Disorders-2 (86%), and that refractory forms of non-migraine headache disorders should be defined (87%). Responders believed a refractory migraine definition would be of greatest value in selecting patients for clinical drug trials. The current refractory migraine definition requires a diagnosis of migraine, interference with function or quality of life despite modification of lifestyle factors, and adequate trials of acute and preventive medicines with established efficacy. The proposed criteria for the refractory migraine definition require failing 2 preventive medications to meet the threshold for failure. Although 42% of respondents agreed with the working definition of refractory migraine, 43% favored increasing the number to 3 (50%) or 4 (26%) preventive treatment failures. When respondents were asked if they felt that the proposed definition was appropriate to select patients for invasive procedures (patent foramen ovale repair or stimulators) only 44% agreed. Conclusions.— There is a consensus for a need for a definition for refractory migraine and that it should be added to the International Classification of Headache Disorder-2. There was also general agreement by the responders that refractory forms of non-migraine headache disorders should be defined.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72860/1/j.1526-4610.2009.01370.x.pd

17α-hydroxylase deficiency diagnosed in early infancy caused by a novel mutation of the CYP17A1 Gene

Mutations of the CYP17A1 gene cause 17α-hydroxylase deficiency (17OHD) resulting in 46,XY disorder of sex development, hypertension, hypokalemia and absent pubertal development. It is a rare, autosomal recessive form of congenital adrenal hyperplasia (CAH).We report on a neonate with prenatally determined 46,XY karyotype. At 20 weeks of gestation, lack of development of male external genitalia was noticed. A phenotypically female child was born at 41 weeks of gestation.Postnatal ultrasound revealed testes in both labia majora, an absence of uterus and normal adrenal glands. Steroid hormone analysis in serum revealed low basal levels of cortisol, testosterone and androstenedione in the presence of massively elevated corticosterone at the age of 2 weeks. The urinary steroid profile from spot urine showed excessive excretion of 17-desoxysteroids, decreased glucocorticoid metabolites and absent C19 steroids, thus proving 17OHD. Molecular analysis identified a novel mutation of the CYP17A1 gene: c.896T>A (p.I299N) in exon 5. Substitution with hydrocortisone was started. The child is raised as a girl and is developing well so far.Herein, we report the unusually early diagnosis of a newborn with the rare CAH form of 17OHD allowing an early start of treatment